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trilovin, impotence, tribulus terrestris, aphrodisiac, trilovin 250, muscle strength, sexual activity


TRILOVIN and TRIBULUS TERRESTRIS
Experimental and Clinical data

TRILOVIN 250
Each tablet contents 250 mg of Tribulus Terrestris (Aerial Part)
Other ingredients: Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Hydroxypropyl Cellulose, Croscarmelose Sodium.

 
TRILOVIN® LIVER FORMULA
Each tablet contents 500 mg of Tribulus Terrestris (Aerial Part), 350 mg of Milk Thistle Extract 80%, 13 mg of bio-active Zinc from Yeast Polypeptide, 270 mg of Folic Acid (60%RDA). Other ingredients: Stearic Acid, Magnesium Stearate, Silicon Dioxide, Hydroxypropyl Cellulose.

History of a patient named D.H.
D.H. is a 54 year old male who was seen in our clinic about a year and a half ago. He complained of fatigue and low sex drive. Overall he had no other serious complaints. His physical exam was essentially unremarkable. We did laboratory studies on him. The total Testosterone was about 297 and free Testosterone was about 54. The percent of free Testosterone was about 1.87 and the PSA was about 1.5. He was started on Pharmabul Inc. Tribulus terrestris L herbal product Trilovin 250. Intermittently, the patient was evaluated in the clinic and he reported improved strength and energy level. Additionally, his sex drive was much improved.

At his annual physical exam one year later, the patient was re-evaluated and he seemed to be in very good spirit and full of energy. He reported that he had increased his exercise activity an improved his diet. Furthermore, his mood and zest for life seemed to have also improved.

We repeated his laboratory studies, at this time, and there was market improvement in his total and free Testosterone. Based on attached laboratory report, his Testosterone level had improved by 100 % (total Testosterone- 540, free Testosterone- 185, percent free Testosterone- 1.95). The PSA was reduced to about 1.1. This is most impressive patient result we have had on Trilovin 250 as the main treatment for low Testosterone. We chose him as a case study because he was not taking other supplements that could impact on the results we obtained.

This case goes to show that Trilovin 250 is well worth further study for the treatment of Hypogonadism in males. We have several other patients on Trilovin 250 who are taking other supplements with similar results as above, however, we could not isolate Trilovin 250 as the only cause of changes we observed in them. In the current case, the patient was consistent and complaint with taking Trilovin 250 at 4 tablets a day for 1 year. The results obtained therefore reflect the impact of Trilovin 250.

This case therefore, suggests that Trilovin 250 has tremendous potential for management of Hypogonadism in males.

CHIEDU J. NCHEKWUBE, M.D.,F.A.A.F.P., FAMILY MEDICINE AND WELLNESS CENTER.
MERILLVILLE, USA

 

Effect on liver function test and hepatitis-C viral load in one patient
The patient is a 48-year-old male, previous intravenous drug abuser, who was diagnosed with Hepatitis-C, in November 1999. He was a symptomatic. The diagnosis was prompted by an abnormal liver function test, on a routine yearly health evaluation. At the time of evaluation he had been off illicit drugs for at least five years.

On physical evaluation, the liver was slightly and rather on the firm side. The rest of his physical exam was otherwise not significant.

Laboratory test revealed elevated liver enzymes. Subsequent screening for hepatitis B and C was positive for the B surface antibody and HCV antibody. The hepatitis C RNA quantitative test by the Chiron method done on 11/22/99 was 2,650,000. A repeat quantitative hepatitis C viral RNA by PCR done on 10/20/2000 was 392,000.

On 9/14/2001, HCV RNA quantitative by PCR method revealed a vital load of >850,000; with a sensitivity limit of 300,000 - 850,000.

At this point, Trilovin Liver Formula was started on the recommended dose, in addition to all the other supplements he had always taken. The patient was very diligent in taking his supplements. On 7/15/2002, the HCV RNA quantitative by PCR method revealed a viral load of 334,000; with a sensitivity limit of 300,000-850,000.

The above laboratory finding suggests that the addition on Trilovin Liver formula may have affected the remarkable drop in the Hepatitis C rival load in this patient. It is worthwhile to mention that from 7/7/99 to 9/14/2001, the patient was on another popular brand of Silymarin supplement, prior to being placed on Trilovin Liver formula.

Given the above encouraging and very preliminary finding, in this patient, Trilovin Liver formula deserves an expanded study, to further elucidate its value in the treatment of Hepatitis-C.

This expanded study is all the more cogent, in the light of the poor response to conventional treatment by a large section of the population in the U.S.

This report was submitted by:
CHIEDU J. NCHEKWUBE, M.D.,F.A.A.F.P., FAMILY MEDICINE AND WELLNESS CENTER.
MERILLVILLE, USA

A novel furostanol saponin from Tribulus terrestris of Bulgarian origin
Conrad J, Dinchev D, Klaiber I, Mika S, Kostova I, Kraus W.
Fitoterapia. 2004 Mar;75(2):117-22.

Department of Chemistry, University of Hohenheim, 70593 Stuttgart, Germany.
The phytochemical investigation of the aerial parts of Tribulus terrestris of Bulgarian origin has resulted in the isolation of the novel furostanol saponin 1, named tribol, together with the known spirostanol saponins 2 and 3 and sitosterol glucoside. The structure of tribol was determined as (25R)-furost-5(6)-ene-3beta,16,26-triol-3-O-alpha-rhamnopyranosyl-(1-->2)-[alpha-rhamnopyranosyl-(1-->4)]-beta-glucopyranoside (1) by spectral analysis, including extensive 1D and 2D-NMR experiments.

Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity
Sharifi AM, Darabi R, Akbarloo N.
Life Sci. 2003 Oct 24;73(23):2963-71.

Department of Pharmacology, Razi Institute for Drug Research and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, PO Box 14155-6183 Tehran, Iran.
Tribulus terrestris is a natural herb used for treating many diseases including hypertension. According to previous reports, aqueous extract of tribulus fruits may have some antihypertensive effect with an unknown mechanism. The present study investigated the antihypertensive mechanism of tribulus in 2K1C hypertensive rats by measurement of circulatory and local ACE activity in aorta, heart, kidney and lung. Four groups of rats were selected; control, sham, operated or hypertensive and tribulus treated hypertensive group. Hypertension was induced using silver clip on renal artery by surgery. Four weeks after surgery, a single daily dose of 10 mg/kg of lyophilized aqueous extract of tribulus fruit were given orally to 2K1C rats for four weeks. ACE activity was determined by high performance liquid chromatography (HPLC). Blood pressure was measured by the tail-cuff method. The systolic blood pressure (SBP) was significantly increased in 2K1C rats compared to control rats. The SBP of tribulus fed hypertensive rats was significantly decreased compared to hypertensive rats. The ACE activity in all tissues of 2K1C rats including: aorta, heart, kidney, lung as well as serum were significantly increased compared to normal rats. The ACE activity in all tissues of tribulus fed hypertensive rats was significantly lower than that of hypertensive rats, which was more pronounced in kidney. These results indicated that there is a negative correlation between consumption of tribulus and ACE activity in serum and different tissues in 2K1C rats.


Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model
Gauthaman K, Ganesan AP, Prasad RN.
J Altern Complement Med. 2003 Apr;9(2):257-65.

Department of Obstetrics and Gynaecology, National University Hospital, National University of Singapore, Singapore.
OBJECTIVE: Apart from its claims for improvement of sexual functions in men, the puncturevine plant (Tribulus terrestris: TT) has long been considered as an energizer and vitalizer in the indigenous system of medicine. Sexual behavior and intracavernous pressure (ICP) measurements were taken in rats to scientifically validate the claim of TT [containing protodioscin (PTN)] as an aphrodisiac. MATERIALS AND METHODS: Forty sexually mature male Sprague-Dawley rats were randomly divided into four groups of 10 each. Group I served as a control group and groups II, III, and IV were treated with three different doses of TT extract (2.5, 5 and 10 mg/kg body weight, respectively), orally, once daily for 8 weeks. Weight was recorded and the rats from all four groups were subjected to sexual behavior studies with primed females and various parameters namely mount and intromission frequencies (MF and IF, respectively), mount, intromission and ejaculation latencies (ML, IL, and EL, respectively) as well as postejaculatory interval (PEI) were recorded. In addition, blood pressure and ICP were recorded for all rats at the end of study. RESULTS: Increases in body weight (by 9, 23, and 18% for groups II, III & IV) and ICP (by 43% and 26% for groups III and IV) were statistically significant compared to the control group. Increases in MF (by 27% and 24%) and IF (by 19% and 22%) for the groups III and IV were statistically significant. Decreases in ML (by 16%, 23%, and 22% for groups II, III, and IV) and PEI (by 20% for group III) were statistically significant compared to the control. CONCLUSIONS: The weight gain and improvement in sexual behavior parameters observed in rats could be secondary to the androgen increasing property of TT (PTN) that was observed in our earlier study on primates. The increase in ICP which confirms the proerectile aphrodisiac property of TT could possibly be the result of an increase in androgen and subsequent release of nitric oxide from the nerve endings innervating the corpus cavernosum.

Hypoglycemic effect of saponin from Tribulus terrestris
Li M, Qu W, Wang Y, Wan H, Tian C.
Zhong Yao Cai. 2002 Jun;25(6):420-2.

School of Life Science, East China Normal University, Shanghai 200062.
OBJECTIVE: To study the hypoglycemic effect of saponin from Tribulus terrestris L. METHOD: Alloxan was used to establish the diabetic model in mice. Phenformin Hydrochlride Tables was used as the positive control. The level of glucose, triglyceride, cholesterol and SOD in serum were determined. RESULTS: The level of serum glucose could be significantly reduced by saponin from Tribulus terrestris, which was the rate of 26.25% and 40.67% in normal mice and diabetic mice in respectively. The level of serum triglyceride could be reduced 23.35%. The saporin could also decrease the content of serum cholesterol. Serum SOD activity of the mice was increased by the saponin. CONCLUSION: Saponin from Tribulue terrestris could significantly reduce the level of serum glucose.


Biologically active steroidal glycosides from Tribulus terrestris
Bedir E, Khan IA, Walker LA.
Pharmazie. 2002 Jul;57(7):491-3.

National Center for Natural Products Research, University of Mississippi, USA.
The steroidal saponin constituents obtained from Tribulus terrestris were tested for their antimicrobial and cytotoxic effects. The spirostanol-based steroidal saponins 1-3 exhibited remarkable activity against fungal organisms (Candida albicans and Cryptococcus neoformans) and cancer cell lines [human malignant melanoma (SK-MEL), human oral epidermoid carcinoma (KB), human breast ductal carcinoma (BT-549), and human ovary carcinoma (SK-OV-3)], while none of the compounds possessing the furostanol framework 4-7 showed activity. The most active spirostanol glycoside, compound 3 exhibited a broad range of anticancer activity against cell lines, SK-MEL, KB, BT-549 and SK-OV-3 at IC50s of 6.0, 7.0, 6.0 and 8.2 micrograms/ml, respectively, while compounds 1 and 2 showed selective cytotoxicity against SK-MEL at 6.7 and 9.1 micrograms/ml, respectively. The minimum inhibitory concentrations (MIC) in antifungal bioassay for compounds 1-3 varied from 1.5 to 6.2 micrograms/ml, which prompted to conclude certain structural features are required for these bioactivities.


The effects of Tribulus terrestris on body composition and exercise performance in resistance-trained males
Antonio J, Uelmen J, Rodriguez R, Earnest C.
Int J Sport Nutr Exerc Metab. 2000 Jun;10(2):208-15.

Human Performance Laboratory, University of Nebraska, Kearney, NE 68849-3101, USA.
The purpose of this study was to determine the effects of the herbal preparation Tribulus terrestris (tribulus) on body composition and exercise performance in resistance-trained males. Fifteen subjects were randomly assigned to a placebo or tribulus (3.21 mg per kg body weight daily) group. Body weight, body composition, maximal strength, dietary intake, and mood states were determined before and after an 8-week exercise (periodized resistance training) and supplementation period. There were no changes in body weight, percentage fat, total body water, dietary intake, or mood states in either group. Muscle endurance (determined by the maximal number of repetitions at 100-200% of body weight) increased for the bench and leg press exercises in the placebo group (p <.05; bench press +/-28.4%, leg press +/-28.6%), while the tribulus group experienced an increase in leg press strength only (bench press +/-3.1%, not significant; leg press +/-28.6%, p <.05). Supplementation with tribulus does not enhance body composition or exercise performance in resistance-trained males.


Effect of Tribulus terrestris L. saponin mixture on some smooth muscle preparations: a preliminary study
Arcasoy HB, Erenmemisoglu A, Tekol Y, Kurucu S, Kartal M.
Boll Chim Farm. 1998 Dec;137(11):473-5.

Department of Pharmacology, Faculty of Medicine, Erciyes University Kayseri, Turkey.
Tribulus terrestris L. is an annual plant which has been commonly used in folk medicine as diuretic and against colic pains, hypertension and hypercholesterolemia in Turkey. This study investigated the effects of liophilized saponin mixture of this plant on several smooth muscle preparations in vitro. The liophilized material was obtained from dried and powdered T. terrestris L. by specific extraction method for saponins. Median lethal dose (LD50) of saponin mixture on Swiss albino mice was calculated according to Litchfield-Wilcoxon method via i.p. route. LD50 and its 95% confidence limits were 813 and 739-894 mg.kg-1 respectively. Saponin mixture has caused a significant decrease on peristaltic movements of isolated sheep ureter and rabbit jejunum preparations in a dose-dependent manner (p < 0.05). However it has been observed no effect on isolated rabbit aorta and its contractile response to KCl or noradrenaline (p > 0.05). According to these results it has been suggested that T. terrestris L. or its saponin mixture may be useful on some smooth muscle spasms or colic pains.


TRILOVIN 250
Trilovin 250 is for Men and Women wishing to improve sexual performance. Trilovin 250 has been shown to increase testosterone levels in men and estradiol and progesterone levels in women. Trilovin 250 can enhance certain aspects of sexual physiology in both men and women.

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TRILOVIN® LIVER FORMULA
Trilovin Liver Formula is a natural herbal preparation to improve liver function, support immune system, improve blood flow, increase red blood cells count, reduce kidney, bladder, prostate and varicose vein inflammation, reduce prostatitis and prostate enlargement, reduce high blood pressure, improve healthy cholesterol, supp, helping the body transport oxygen, especially in older men, natural healing of bacterial, virus and herpes infection.

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