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Milgamma NEURO against diabetic neuropathy. Special combination of Vitamins B helps overcome age-related diabetes.


he B vitamins play important roles in cell metabolism. They are water soluble and are usually found in similar food sources such as brewer's yeast, animal meats, cereals and vegetable proteins.Tthey work in the body are closely interrelated. The primary use of this vitamins and antioxidants is as an "anti-AGE" supplements. In the recent development, researchers have developed a new medication for patients suffering from diabetes called by the name of Milgamma. It is basically used to treat certain conditions arising in diabetic patients such as, diabetic nephropathy, retinopathy and neuropathy. It comprises of three active substances: pyridoxine, cyanocobalamin and benfotiamine. Out of these three substances benfotiamine is a fat soluble form of Vitamin B1 which helps to protect the tissues of the body against advanced glycation and also supports healthy blood sugar metabolism. Benfotiamine helps in increasing transketolase activity in cells by 300%. In a trial, benfotiamine lowered AGE by 40%. Main function of benfotiamine is to activate glucose metabolism and to promote healthy blood glucose levels.

vitamins b

Diabetic nephropathy, retinopathy and neuropathy results due to increase blood sugar level (hyperglycaemia) which leads to accumulation of glucose in muscles. Such deposition enters into the cells and ultimately damages them which can lead to life threatening conditions. Milgamma works by restricting the build up process of such glucose levels in muscles and cells. Cyanocobalamin is a form of Vitamin B12 while pyridoxine gets metabolised in the body to yield Vitamin B6. Along with diabetic neuropathy, milgamma is also used in treatment of other diseases such as radicular syndrome, myodynia, neuralgia, herpes zoster and deficiencies of Vitamin B1 and Vitamin B6.

Milgamma-Neuro is Milgamma Latest modification (1 Tablet contains: 100mg of benfotiamine and 100mg of pyridoxine) was successfully tested in diabetes mellitus type II study. The study was conducted using 14 patients. The drug was given for duration of 6 weeks at the rate of one drug thrice a day. The study result showed that intensity of pain decreases from 8.2 scores to 2.3 scores (according to visual analogous scale). It also resulted in significant improvement in indices of vibratory sensitivity along with data of cardiovascular tests characterizing parasympathetic control of heart rhythm. The sympathetic potentials on arms and legs having longer latent periods became very short. The overall study showed the improvement in 93% of the cases. Benfotiamine, a fat-soluble form of vitamin B1 (thiamine) better absorbed and stored in the tissues longer than the water-soluble tiaminhidroklorid. Pyridoxine improves the loss of motor, sensory and vegetative nerve operation.

ACTIVE SUBSTANCE Benfotiamine Pyridoxin B12-vitamin
Milgamma Neuro coated tablets 100 mg 100 mg  
Milgamma N capsules 40 mg 90 mg 0.25 mg
Milgamma coated tablets 50 mg   0.25 mg

Benfotiamin penetration through the cell membrane



The active substances of milgamma are also individually used as dietary supplements in diabetic patients. Milgamma is non toxic as it is largely a vitamin based drug. The side effects of this drug include itching, skin rashes, redness, hives, excessive sweating, dizziness and irregular heartbeats. Generally it is recommended not to take milgamma if patient is hyper sensitive towards benfotiamine. The pregnant females and breast feeding women can take this medication without any harmful effects, though strict medical supervision is recommended. The drug is available as tablets, dragee and injections. The dosage of milgamma is up to 100mg daily or as per the prescription of doctor. Pregnant women should not take more than 25mg of milgamma per day.

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